04/22/2021
Our paper on the rational design of non-covalent SARS-CoV-2 main protease inhibitors was published in
J. Med. Chem. The non-covalent Mpro inhibitors are highly selective against host cysteine proteases, while the canonical Mpro inhibitors such as GC376 were not selective and inhibited a number of host proteases. The most potent compound 23R occupies a new pocket in Mpro that has not been explored before.
02/25/2021
In a following up study, we have shown that boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against MERS-CoV, SARS-CoV, HCoV-OC43, HCoV-NL63, and HCoV-229E in addition to SARS-CoV-2. More importantly, all four compounds also had potent antiviral activity against SARS-CoV-2 in TMPRSS2-expressing Caco2 cells. Check our recent publication in ACS Infect. Dis.
02/09/2021
Our paper entitled "The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor" was accepted by Emerging Microbes and Infections. In this study, we have shown the lactoferrin, a natural protein that is abundant in milk, inhibits multiple coronaviruses including SARS-CoV-2 by preventing the binding of the virus to the host heparan sulfate attachment factor. Check this paper at www.tandfonline.com/doi/full/10.1080/22221751.2021.1888660
1/21/2021
Our letter to the editor entitled "Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors" was accepted by
Proc. Natl. Acad. Sci. U S A. In this communication, we provided experimental evidence to invalidate the previous reported SARS-CoV-2 main protease inhibitor in this paper www.pnas.org/content/117/44/27381
11/6/2020
Our Science Advances paper is online! Check it out!
https://advances.sciencemag.org/content/early/2020/11/05/sciadv.abe0751
11/5/2020
Dr. Wang is honored to be elected as the editorial board member of the European Journal of Pharmaceutical Sciences, which he has reviewed more than 80 manuscripts so far! Check it out:
www.journals.elsevier.com/european-journal-of-pharmaceutical-sciences/editorial-board
11/1/2020
In this preprint we have shown that boceprevir, calpain inhibitors II and XII, and GC-376 not only inhibits SARS-CoV-2, but also SARS-CoV, MERS-CoV, and seasonal human coronaviruses HCoV-NL63, HCoV-229E, and HCoV-OC43.
https://www.biorxiv.org/content/10.1101/2020.10.30.362335v1
Check out the news coverage of this study at News Medical Life Sciences.
Discovery of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376
10/14/2020
Our manuscript entitled "Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L" was accepted by Science Advances. Thanks to our collaborators Dr. Yu Chen (USF), Dr. Michael Marty (UA), Dr. Yan Xiang (UTSA), Dr. Brett Hurst and Dr. Bart Tarbet (USU) for their contribution!
Our paper on the rational design of non-covalent SARS-CoV-2 main protease inhibitors was published in
J. Med. Chem. The non-covalent Mpro inhibitors are highly selective against host cysteine proteases, while the canonical Mpro inhibitors such as GC376 were not selective and inhibited a number of host proteases. The most potent compound 23R occupies a new pocket in Mpro that has not been explored before.
02/25/2021
In a following up study, we have shown that boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against MERS-CoV, SARS-CoV, HCoV-OC43, HCoV-NL63, and HCoV-229E in addition to SARS-CoV-2. More importantly, all four compounds also had potent antiviral activity against SARS-CoV-2 in TMPRSS2-expressing Caco2 cells. Check our recent publication in ACS Infect. Dis.
02/09/2021
Our paper entitled "The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor" was accepted by Emerging Microbes and Infections. In this study, we have shown the lactoferrin, a natural protein that is abundant in milk, inhibits multiple coronaviruses including SARS-CoV-2 by preventing the binding of the virus to the host heparan sulfate attachment factor. Check this paper at www.tandfonline.com/doi/full/10.1080/22221751.2021.1888660
1/21/2021
Our letter to the editor entitled "Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors" was accepted by
Proc. Natl. Acad. Sci. U S A. In this communication, we provided experimental evidence to invalidate the previous reported SARS-CoV-2 main protease inhibitor in this paper www.pnas.org/content/117/44/27381
11/6/2020
Our Science Advances paper is online! Check it out!
https://advances.sciencemag.org/content/early/2020/11/05/sciadv.abe0751
11/5/2020
Dr. Wang is honored to be elected as the editorial board member of the European Journal of Pharmaceutical Sciences, which he has reviewed more than 80 manuscripts so far! Check it out:
www.journals.elsevier.com/european-journal-of-pharmaceutical-sciences/editorial-board
11/1/2020
In this preprint we have shown that boceprevir, calpain inhibitors II and XII, and GC-376 not only inhibits SARS-CoV-2, but also SARS-CoV, MERS-CoV, and seasonal human coronaviruses HCoV-NL63, HCoV-229E, and HCoV-OC43.
https://www.biorxiv.org/content/10.1101/2020.10.30.362335v1
Check out the news coverage of this study at News Medical Life Sciences.
Discovery of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376
10/14/2020
Our manuscript entitled "Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L" was accepted by Science Advances. Thanks to our collaborators Dr. Yu Chen (USF), Dr. Michael Marty (UA), Dr. Yan Xiang (UTSA), Dr. Brett Hurst and Dr. Bart Tarbet (USU) for their contribution!